Document Type

Article

Publication Date

4-8-2025

Abstract

Background: There is growing interest in washing banked blood with an intraoperative autotransfusion device (IAT) prior to transfusing to patients. The main purpose of this practice is to reduce the effects caused by storage lesion, both to the blood and the patient, and diminish the cost and of washing by using an IAT as opposed to washing in the blood bank.

Objective: The objective of this scoping review is to summarize the existing data on the use of IATs for washing stored banked blood and evaluate the potential advantages and disadvantages associated with transfusing the washed blood.

Method: This scoping review utilized the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines with a comprehensive literature search across three databases from the invention of the cell salvage device in 1943 to January 2025. Ten studies were found and results from them were summarized, compared, and analyzed to determine potential benefits and drawbacks of washing banked blood with an IAT.

Results: Analysis of the ten studies postulates the advantage of washing banked blood to reduce potassium, lactate, lactate dehydrogenase, and microparticles while disadvantages include decreasing 2,3-diphosphoglycerate and adenosine triphosphate levels as well as a potential increase in plasma-free hemoglobin. However, data is sparse and not standardized, making it difficult to compare and give true support to clinical usage.

Conclusions: This scoping review provides an overview and analysis of the current data available concerning the potential advantages and disadvantages of washing banked blood using an IAT. The current data is varied but offers a framework for further studies that may look into more specific details about physiological blood components or specific cell salvage devices.

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