Document Type
Article
Publication Date
4-21-2026
Abstract
ABSTRACT
- Structured summary
Background
Cardiopulmonary bypass (CPB) is essential in cardiac surgery but can trigger a systemic inflammatory response that contributes to postoperative complications. The scoping review conducted has a purpose to map the existing literature on pharmacologic interventions to mitigate CPB related inflammation. While several interventions demonstrated potential anti-inflammatory effects, findings were inconsistent, and no standardized pharmacologic approach is currently agreed upon.
Methods
This scoping review followed PRISMA-ScR guidelines.Both PubMed, and CINAHL were screened for studies published between 2000 and 2024 that evaluated pharmacologic interventions aimed at reducing CPB related inflammation. After screening and duplicate removal, 10 studies met the inclusion criteria for analysis.
Results
10 studies were included in this scoping review. Five categories were identified: albumin based priming solutions, corticosteroids, statins, antifibrinolytic/protease inhibitors, and phosphodiesterase inhibitors. Each section showed promising insight, but some were lacking in data to back any significance.
Conclusions
This scoping review highlights that while several pharmacologic strategies show potential in mitigating CPB induced inflammation, there are still no standardized approaches currently agreed upon.
Keywords
Cardiopulmonary bypass, inflammation, pharmacologic intervention, corticosteroids, statins, tranexamic acid, antifibrinolytics, albumin, phosphodiesterase inhibitors, cardiac surgery, inflammatory markers.
Recommended Citation
Anderson, Wyatt, "Pharmacologic Interventions to Reduce Cardiopulmonary Bypass Induced Inflammation in Cardiac Surgery: A Scoping Review" (2026). Student Works. 18.
https://digitalcollections.lipscomb.edu/cper_student/18
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.